7EQV

Crystal structure of JMJD2A complexed with 3,4-dihydroxybenzoic acid

Summary for 7EQV

Entry DOI	10.2210/pdb7eqv/pdb
Descriptor	Lysine-specific demethylase 4A, 3,4-DIHYDROXYBENZOIC ACID, NICKEL (II) ION, ... (6 entities in total)
Functional Keywords	human histone lysine demethylase 4a, lysine-specific demethylase 4a, kdm4a, jmjd2a, 3, 4-dihydroxybenzoic acid, inhibitor, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	40887.01
Authors	Fang, W.-K.,Yang, S.-M.,Wang, W.-C. (deposition date: 2021-05-04, release date: 2022-05-18, Last modification date: 2023-11-29)
Primary citation	Liu, J.S.,Fang, W.K.,Yang, S.M.,Wu, M.C.,Chen, T.J.,Chen, C.M.,Lin, T.Y.,Liu, K.L.,Wu, C.M.,Chen, Y.C.,Chuu, C.P.,Wang, L.Y.,Hsieh, H.P.,Kung, H.J.,Wang, W.C. Natural product myricetin is a pan-KDM4 inhibitor which with poly lactic-co-glycolic acid formulation effectively targets castration-resistant prostate cancer. J.Biomed.Sci., 29:29-29, 2022 Cited by PubMed: 35534851 DOI: 10.1186/s12929-022-00812-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation