7EO5

Crystal structure of pyrano 1,3, oxazine derivative in complex with the second bromodomain of BRD2

Summary for 7EO5

Entry DOI	10.2210/pdb7eo5/pdb
Descriptor	Bromodomain-containing protein 2, TRIETHYLENE GLYCOL, 7-chloranyl-2-[(3-chlorophenyl)amino]pyrano[3,4-e][1,3]oxazine-4,5-dione, ... (4 entities in total)
Functional Keywords	bet family, brd2, bromodomain, b-mercaptoethanol, cme, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	13881.60
Authors	Padmanabhan, B.,Arole, A.,Deshmukh, P.,Ashok, S. (deposition date: 2021-04-21, release date: 2022-03-09, Last modification date: 2023-11-29)
Primary citation	Arole, A.H.,Deshmukh, P.,Sridhar, A.,Padmanabhan, B. Structural investigation of a pyrano-1,3-oxazine derivative and the phenanthridinone core moiety against BRD2 bromodomains. Acta Crystallogr.,Sect.F, 78:119-127, 2022 Cited by PubMed: 35234137 DOI: 10.1107/S2053230X22001066 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation