7EO5
Crystal structure of pyrano 1,3, oxazine derivative in complex with the second bromodomain of BRD2
Summary for 7EO5
Entry DOI | 10.2210/pdb7eo5/pdb |
Descriptor | Bromodomain-containing protein 2, TRIETHYLENE GLYCOL, 7-chloranyl-2-[(3-chlorophenyl)amino]pyrano[3,4-e][1,3]oxazine-4,5-dione, ... (4 entities in total) |
Functional Keywords | bet family, brd2, bromodomain, b-mercaptoethanol, cme, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 13881.60 |
Authors | Padmanabhan, B.,Arole, A.,Deshmukh, P.,Ashok, S. (deposition date: 2021-04-21, release date: 2022-03-09, Last modification date: 2023-11-29) |
Primary citation | Arole, A.H.,Deshmukh, P.,Sridhar, A.,Padmanabhan, B. Structural investigation of a pyrano-1,3-oxazine derivative and the phenanthridinone core moiety against BRD2 bromodomains. Acta Crystallogr.,Sect.F, 78:119-127, 2022 Cited by PubMed: 35234137DOI: 10.1107/S2053230X22001066 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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