7ENV
crystal structure of NS5 in complex with the N-terminal bromodomain of BRD2 (BRD2-BD1).
Summary for 7ENV
| Entry DOI | 10.2210/pdb7env/pdb |
| Descriptor | Bromodomain-containing protein 2, 7-chloranyl-2-[(3-chlorophenyl)amino]pyrano[3,4-e][1,3]oxazine-4,5-dione, SULFATE ION, ... (4 entities in total) |
| Functional Keywords | bet family, bet inhibitor, bromodomain inhibitor, brd2-bd1 inhibitor, transcription-inhibitor complex, transcription/inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 3 |
| Total formula weight | 43836.76 |
| Authors | Padmanabhan, B.,Arole, A.,Deshmukh, P.,Ashok, S. (deposition date: 2021-04-19, release date: 2022-03-09, Last modification date: 2023-11-29) |
| Primary citation | Arole, A.H.,Deshmukh, P.,Sridhar, A.,Padmanabhan, B. Structural investigation of a pyrano-1,3-oxazine derivative and the phenanthridinone core moiety against BRD2 bromodomains. Acta Crystallogr.,Sect.F, 78:119-127, 2022 Cited by PubMed: 35234137DOI: 10.1107/S2053230X22001066 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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