7EM7

Crystal structure of the PI5P4Kbeta N203D-XTP complex

7EM7 の概要

• エントリーDOI: 10.2210/pdb7em7/pdb
• 分子名称: Phosphatidylinositol 5-phosphate 4-kinase type-2 beta, [(2~{R},3~{S},4~{R},5~{R})-5-[2,6-bis(oxidanylidene)-3~{H}-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl phosphono hydrogen phosphate, [[(2~{R},3~{S},4~{R},5~{R})-5-[2,6-bis(oxidanylidene)-3~{H}-purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate (3 entities in total)
• 機能のキーワード: lipid kinase, phosphoinositide signaling, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 90828.13

構造登録者

Senda, M.,Senda, T. (登録日: 2021-04-13, 公開日: 2022-03-30, 最終更新日: 2023-11-29)

• 主引用文献: Takeuchi, K.,Ikeda, Y.,Senda, M.,Harada, A.,Okuwaki, K.,Fukuzawa, K.,Nakagawa, S.,Yu, H.Y.,Nagase, L.,Imai, M.,Sasaki, M.,Lo, Y.H.,Ito, D.,Osaka, N.,Fujii, Y.,Sasaki, A.T.,Senda, T.; The GTP responsiveness of PI5P4K beta evolved from a compromised trade-off between activity and specificity.; Structure, 30:886-899.e4, 2022; PubMed: 35504278; DOI: 10.1016/j.str.2022.04.004

実験手法

X-RAY DIFFRACTION (3.45 Å)