7ELW

Crystal structure of RNase L in complex with Myricetin

7ELW の概要

• エントリーDOI: 10.2210/pdb7elw/pdb
• 分子名称: Ribonuclease L, [[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate, 3,5,7-TRIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE, ... (4 entities in total)
• 機能のキーワード: rnase l, inhibitor, myricetin, hydrolase
• 由来する生物種: Sus scrofa (Pig)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 165718.30

構造登録者

Tang, J.,Huang, H. (登録日: 2021-04-12, 公開日: 2021-11-24, 最終更新日: 2023-11-29)

• 主引用文献: Tang, J.,Dong, B.,Liu, M.,Liu, S.,Niu, X.,Gaughan, C.,Asthana, A.,Zhou, H.,Xu, Z.,Zhang, G.,Silverman, R.H.,Huang, H.; Identification of Small Molecule Inhibitors of RNase L by Fragment-Based Drug Discovery; J.Med.Chem., 65:1445-1457, 2022; DOI: 10.1021/acs.jmedchem.1c01156

実験手法

X-RAY DIFFRACTION (3.55 Å)