7EI2
Structure of human NNMT in complex with macrocyclic peptide 8
Summary for 7EI2
Entry DOI | 10.2210/pdb7ei2/pdb |
Descriptor | Nicotinamide N-methyltransferase, macrocyclic peptide 8 (3 entities in total) |
Functional Keywords | nicotinamide n-methyltransferase, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 30066.54 |
Authors | Hayashi, K.,Mikamiyama, H.,Uehara, S.,Yamamoto, S.,Cary, D.,Nishikawa, J.,Ueda, T.,Ozasa, H.,Mihara, K.,Yoshimura, N.,Kawai, T.,Ono, T.,Yamamoto, S.,Fumoto, M. (deposition date: 2021-03-30, release date: 2022-03-30, Last modification date: 2023-11-29) |
Primary citation | Hayashi, K.,Uehara, S.,Yamamoto, S.,Cary, D.R.,Nishikawa, J.,Ueda, T.,Ozasa, H.,Mihara, K.,Yoshimura, N.,Kawai, T.,Ono, T.,Yamamoto, S.,Fumoto, M.,Mikamiyama, H. Macrocyclic Peptides as a Novel Class of NNMT Inhibitors: A SAR Study Aimed at Inhibitory Activity in the Cell. Acs Med.Chem.Lett., 12:1093-1101, 2021 Cited by PubMed: 34267879DOI: 10.1021/acsmedchemlett.1c00134 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.08 Å) |
Structure validation
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