7EBW
Crystal structure of Aedes aegypti Noppera-bo, glutathione S-transferase epsilon 8, in desmethylglycitein and glutathione-bound form
Summary for 7EBW
| Entry DOI | 10.2210/pdb7ebw/pdb |
| Descriptor | Glutathione transferase, GLUTATHIONE, 6,7-dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one, ... (5 entities in total) |
| Functional Keywords | glutathione, glutathione s-transferase, gst, transferase |
| Biological source | Aedes aegypti (Yellowfever mosquito, Culex aegypti) |
| Total number of polymer chains | 4 |
| Total formula weight | 106909.00 |
| Authors | Inaba, K.,Koiwai, K.,Senda, M.,Senda, T.,Niwa, R. (deposition date: 2021-03-11, release date: 2022-01-26, Last modification date: 2023-11-29) |
| Primary citation | Inaba, K.,Ebihara, K.,Senda, M.,Yoshino, R.,Sakuma, C.,Koiwai, K.,Takaya, D.,Watanabe, C.,Watanabe, A.,Kawashima, Y.,Fukuzawa, K.,Imamura, R.,Kojima, H.,Okabe, T.,Uemura, N.,Kasai, S.,Kanuka, H.,Nishimura, T.,Watanabe, K.,Inoue, H.,Fujikawa, Y.,Honma, T.,Hirokawa, T.,Senda, T.,Niwa, R. Molecular action of larvicidal flavonoids on ecdysteroidogenic glutathione S-transferase Noppera-bo in Aedes aegypti. Bmc Biol., 20:43-43, 2022 Cited by PubMed Abstract: Mosquito control is a crucial global issue for protecting the human community from mosquito-borne diseases. There is an urgent need for the development of selective and safe reagents for mosquito control. Flavonoids, a group of chemical substances with variable phenolic structures, such as daidzein, have been suggested as potential mosquito larvicides with less risk to the environment. However, the mode of mosquito larvicidal action of flavonoids has not been elucidated. PubMed: 35172816DOI: 10.1186/s12915-022-01233-2 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.94 Å) |
Structure validation
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