7E8D
NSD2 E1099K mutant bound to nucleosome
Summary for 7E8D
Entry DOI | 10.2210/pdb7e8d/pdb |
EMDB information | 31015 |
Descriptor | Histone H3.1, Histone H4, Histone H2A type 1, ... (9 entities in total) |
Functional Keywords | chromatin, epigenetics, histone methyltransferase, muitiple myeloma, gene regulation |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 11 |
Total formula weight | 252528.67 |
Authors | Sengoku, T.,Sato, K.,Nishizawa, T.,Nureki, O.,Ogata, K. (deposition date: 2021-03-01, release date: 2021-11-10, Last modification date: 2024-06-05) |
Primary citation | Sato, K.,Kumar, A.,Hamada, K.,Okada, C.,Oguni, A.,Machiyama, A.,Sakuraba, S.,Nishizawa, T.,Nureki, O.,Kono, H.,Ogata, K.,Sengoku, T. Structural basis of the regulation of the normal and oncogenic methylation of nucleosomal histone H3 Lys36 by NSD2. Nat Commun, 12:6605-6605, 2021 Cited by PubMed: 34782608DOI: 10.1038/s41467-021-26913-5 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.8 Å) |
Structure validation
Download full validation report