7E6E

Crystal structure of PMP-bound form of cysteine desulfurase SufS R376A from Bacillus subtilis in D-cycloserine-inhibition

Summary for 7E6E

• Entry DOI: 10.2210/pdb7e6e/pdb
• Descriptor: Cysteine desulfurase SufS, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, TETRAETHYLENE GLYCOL, ... (6 entities in total)
• Functional Keywords: cysteine desulfurase, plp-dependent enzyme, cysteine metabolism, cycloserine, inhibitor, fe-s cluster biosynthesis, biosynthetic protein
• Biological source: Bacillus subtilis subsp. subtilis str. 168
• Total number of polymer chains: 1
• Total formula weight: 47739.75

Authors

Nakamura, R.,Takahashi, Y.,Fujishiro, T. (deposition date: 2021-02-22, release date: 2022-03-02, Last modification date: 2023-11-29)

• Primary citation: Nakamura, R.,Ogawa, S.,Takahashi, Y.,Fujishiro, T.; Cycloserine enantiomers inhibit PLP-dependent cysteine desulfurase SufS via distinct mechanisms.; Febs J., 289:5947-5970, 2022; PubMed: 35395703; DOI: 10.1111/febs.16455

Experimental method

X-RAY DIFFRACTION (2.28 Å)