7E5F

HUMAN PPAR ALPHA LIGAND BINDING DOMAIN IN COMPLEX WITH TIPP703 OBTAINED BY SOAKING

Summary for 7E5F

• Entry DOI: 10.2210/pdb7e5f/pdb
• Related: 2znn
• Descriptor: Peroxisome proliferator-activated receptor alpha, (2S)-2-(4-propoxy-3-{[({4-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]phenyl}carbonyl)amino]methyl}benzyl)butanoic acid (3 entities in total)
• Functional Keywords: nuclear receptor, ppar, protein-ligand complex, transcription
• Biological source: Homo sapiens
• Total number of polymer chains: 1
• Total formula weight: 31359.72

Authors

Oyama, T.,Kamata, S.,Ishii, I.,Miyachi, H. (deposition date: 2021-02-18, release date: 2021-10-06, Last modification date: 2023-11-29)

• Primary citation: Oyama, T.,Kamata, S.,Ishii, I.,Miyachi, H.; Crystal Structures of the Human Peroxisome Proliferator-Activated Receptor (PPAR) alpha Ligand-Binding Domain in Complexes with a Series of Phenylpropanoic Acid Derivatives Generated by a Ligand-Exchange Soaking Method.; Biol.Pharm.Bull., 44:1202-1209, 2021; PubMed: 34471048; DOI: 10.1248/bpb.b21-00220

Experimental method

X-RAY DIFFRACTION (1.79 Å)