7E5E
Crystal structure of GDP-bound GNAS in complex with the cyclic peptide inhibitor GD20
Summary for 7E5E
Entry DOI | 10.2210/pdb7e5e/pdb |
Related | 7BPH |
Descriptor | Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, GD20, GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total) |
Functional Keywords | g protein, gnas, adenylyl cyclase, inactive state, inhibitor, mrna display, rapid, cyclic peptide, gd20, signaling protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 8 |
Total formula weight | 171382.83 |
Authors | Hu, Q.,Dai, S.,Shokat, K.M. (deposition date: 2021-02-18, release date: 2022-03-02, Last modification date: 2023-11-29) |
Primary citation | Dai, S.A.,Hu, Q.,Gao, R.,Blythe, E.E.,Touhara, K.K.,Peacock, H.,Zhang, Z.,von Zastrow, M.,Suga, H.,Shokat, K.M. State-selective modulation of heterotrimeric G alpha s signaling with macrocyclic peptides. Cell, 185:3950-, 2022 Cited by PubMed: 36170854DOI: 10.1016/j.cell.2022.09.019 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
Download full validation report