7E5E
Crystal structure of GDP-bound GNAS in complex with the cyclic peptide inhibitor GD20
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 348 | 40512.9 | 4 | UniProt (P63092) Pfam (PF00503) In PDB | Homo sapiens (human) | Adenylate cyclase-stimulating G alpha protein |
2 | E, F, G, H | GD20 | polymer | 17 | 1854.2 | 4 | synthetic construct | ||
3 | A, B, C, D | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 4 | Chemie (GDP) | |||
4 | A, B, C, D | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
5 | water | water | 18.0 | 329 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 35 - 394 (UniProt: P63092)
PDB | External Database | Details |
---|---|---|
Gly 33 | - | expression tag |
Pro 34 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 169468.2 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 1914.6 | |
All* | Total formula weight | 171382.8 |