7E5E
Crystal structure of GDP-bound GNAS in complex with the cyclic peptide inhibitor GD20
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Isoform Gnas-2 of Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 348 | 40512.9 | 4 | UniProt (P63092) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-stimulating G alpha protein |
| 2 | E, F, G, H (E, F, G, H) | GD20 | polymer | 17 | 1854.2 | 4 | synthetic construct | ||
| 3 | I, K, M, O (A, B, C, D) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 4 | Chemie (GDP) | |||
| 4 | J, L, N, P (A, B, C, D) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 5 | Q, R, S, T, U... (A, B, C, D, E...) | water | water | 18.0 | 329 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 35 - 394 (UniProt: P63092)
| PDB | External Database | Details |
|---|---|---|
| Gly 33 | - | expression tag |
| Pro 34 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 169468.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1914.6 | |
| All* | Total formula weight | 171382.8 |
