7E3U

Crystal structure of the Pseudomonas aeruginosa dihydropyrimidinase complexed with 5-AU

Summary for 7E3U

• Entry DOI: 10.2210/pdb7e3u/pdb
• Descriptor: D-hydantoinase/dihydropyrimidinase, 5-AMINO-1H-PYRIMIDINE-2,4-DIONE, ZINC ION, ... (4 entities in total)
• Functional Keywords: hydrolase, dihydropyrimidinase
• Biological source: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
• Total number of polymer chains: 2
• Total formula weight: 105020.42

Authors

Yang, Y.C.,Luo, R.H.,Huang, Y.H.,Huang, C.Y.,Lin, E.S. (deposition date: 2021-02-09, release date: 2022-02-16, Last modification date: 2023-11-29)

• Primary citation: Lin, E.S.,Luo, R.H.,Yang, Y.C.,Huang, C.Y.; Molecular Insights into How the Dimetal Center in Dihydropyrimidinase Can Bind the Thymine Antagonist 5-Aminouracil: A Different Binding Mode from the Anticancer Drug 5-Fluorouracil.; Bioinorg Chem Appl, 2022:1817745-1817745, 2022; PubMed: 35198016; DOI: 10.1155/2022/1817745

Experimental method

X-RAY DIFFRACTION (2.159 Å)