7E27
Structure of PfFNT in complex with MMV007839
Summary for 7E27
Entry DOI | 10.2210/pdb7e27/pdb |
EMDB information | 30953 |
Descriptor | Formate-nitrite transporter, (Z)-4,4,5,5,5-pentakis(fluoranyl)-1-(4-methoxy-2-oxidanyl-phenyl)-3-oxidanyl-pent-2-en-1-one (3 entities in total) |
Functional Keywords | lactate transporter, transport protein |
Biological source | Plasmodium falciparum 3D7 |
Total number of polymer chains | 5 |
Total formula weight | 174022.35 |
Authors | |
Primary citation | Peng, X.,Wang, N.,Zhu, A.,Xu, H.,Li, J.,Zhou, Y.,Wang, C.,Xiao, Q.,Guo, L.,Liu, F.,Jia, Z.J.,Duan, H.,Hu, J.,Yuan, W.,Geng, J.,Yan, C.,Jiang, X.,Deng, D. Structural characterization of the Plasmodium falciparum lactate transporter PfFNT alone and in complex with antimalarial compound MMV007839 reveals its inhibition mechanism. Plos Biol., 19:e3001386-e3001386, 2021 Cited by PubMed: 34499638DOI: 10.1371/journal.pbio.3001386 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.29 Å) |
Structure validation
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