7DTS

Crystal structure of RNase L in complex with AC40357

Summary for 7DTS

• Entry DOI: 10.2210/pdb7dts/pdb
• Descriptor: Ribonuclease L, 5'-O-MONOPHOSPHORYLADENYLYL(2'->5')ADENYLYL(2'->5')ADENOSINE, butyl 4-hydroxybenzoate, ... (5 entities in total)
• Functional Keywords: rnase l, fragment, inhibitor, hydrolase
• Biological source: Sus scrofa (Pig)
• Total number of polymer chains: 2
• Total formula weight: 165150.36

Authors

Tang, J.,Huang, H. (deposition date: 2021-01-06, release date: 2021-11-24, Last modification date: 2023-11-29)

• Primary citation: Tang, J.,Dong, B.,Liu, M.,Liu, S.,Niu, X.,Gaughan, C.,Asthana, A.,Zhou, H.,Xu, Z.,Zhang, G.,Silverman, R.H.,Huang, H.; Identification of Small Molecule Inhibitors of RNase L by Fragment-Based Drug Discovery; J.Med.Chem., 65:1445-1457, 2022; DOI: 10.1021/acs.jmedchem.1c01156

Experimental method

X-RAY DIFFRACTION (2.63 Å)