7DT8
Crystal structure of V30M mutated transthyretin in complex with 4-chloro-9-oxo-9H-xanthene-2-carboxylic acid
Summary for 7DT8
Entry DOI | 10.2210/pdb7dt8/pdb |
Descriptor | Transthyretin, CALCIUM ION, 4-chloranyl-9-oxidanylidene-xanthene-2-carboxylic acid, ... (4 entities in total) |
Functional Keywords | inhibitor, complex, t4-binding, amyloidosis, transport protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 35314.63 |
Authors | Kitakami, R.,Yokoyama, T.,Mizuguchi, M. (deposition date: 2021-01-04, release date: 2021-10-13, Last modification date: 2023-11-29) |
Primary citation | Kitakami, R.,Inui, K.,Nakagawa, Y.,Sawai, Y.,Katayama, W.,Yokoyama, T.,Okada, T.,Kanamitsu, K.,Nakagawa, S.,Toyooka, N.,Mizuguchi, M. Inhibitory activities of anthraquinone and xanthone derivatives against transthyretin amyloidogenesis. Bioorg.Med.Chem., 44:116292-116292, 2021 Cited by PubMed: 34225167DOI: 10.1016/j.bmc.2021.116292 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.25 Å) |
Structure validation
Download full validation report