7DPO
Crystal Structure of BRD2(BD2)with Ligand ZB-BD-224 bound
Summary for 7DPO
| Entry DOI | 10.2210/pdb7dpo/pdb |
| Descriptor | Bromodomain-containing protein 2, 5-(1-naphthoyl)-11-methyl-8-((methylsulfonyl)methyl)-4,5-dihydro-2,3a1,5-triazadibenzo[cd,h]azulen-1(2H)-one (3 entities in total) |
| Functional Keywords | antitumor; bet proteins; bromodomain inhibitor; epigenetic readers, antitumor protein |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 13681.71 |
| Authors | |
| Primary citation | Li, Z.,Lu, T.,Chen, P.,Luo, C.,Zgou, B. Structure Base Design of A new chemotype of Four-Cycle Compounds as Bromodomain and Extra-Terminal (BET) Inhibitors with The Second Bromodomain Bias and Highly Anti-inflammatory Potency To Be Published, |
| Experimental method | X-RAY DIFFRACTION (2.29994028999 Å) |
Structure validation
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