7DPO

Crystal Structure of BRD2(BD2)with Ligand ZB-BD-224 bound

Summary for 7DPO

• Entry DOI: 10.2210/pdb7dpo/pdb
• Descriptor: Bromodomain-containing protein 2, 5-(1-naphthoyl)-11-methyl-8-((methylsulfonyl)methyl)-4,5-dihydro-2,3a1,5-triazadibenzo[cd,h]azulen-1(2H)-one (3 entities in total)
• Functional Keywords: antitumor; bet proteins; bromodomain inhibitor; epigenetic readers, antitumor protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 13681.71

Authors

Li, Z.,Lu, T.,Chen, P.,Luo, C.,Zhou, B. (deposition date: 2020-12-21, release date: 2021-12-22, Last modification date: 2023-11-29)

• Primary citation: Li, Z.,Lu, T.,Chen, P.,Luo, C.,Zgou, B.; Structure Base Design of A new chemotype of Four-Cycle Compounds as Bromodomain and Extra-Terminal (BET) Inhibitors with The Second Bromodomain Bias and Highly Anti-inflammatory Potency; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.29994028999 Å)