7DPN

Crystal structure of BRD2(BD1)with ligand ZB-BD-224 bound

7DPN の概要

• エントリーDOI: 10.2210/pdb7dpn/pdb
• 分子名称: Bromodomain-containing protein 2, 5-(1-naphthoyl)-11-methyl-8-((methylsulfonyl)methyl)-4,5-dihydro-2,3a1,5-triazadibenzo[cd,h]azulen-1(2H)-one (3 entities in total)
• 機能のキーワード: antitumor; bet proteins; bromodomain inhibitor; epigenetic readers, antitumor protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 44410.73

構造登録者

Li, Z.,Lu, T.,Chen, P.,Luo, C.,Zhou, B. (登録日: 2020-12-20, 公開日: 2021-12-22, 最終更新日: 2023-11-29)

• 主引用文献: Li, Z.,Lu, T.,Chen, P.,Luo, C.,Zgou, B.; Structure Base Design of A new chemotype of Four-Cycle Compounds as Bromodomain and Extra-Terminal (BET) Inhibitors with The Second Bromodomain Bias and Highly Anti-inflammatory Potency; To Be Published,

実験手法

X-RAY DIFFRACTION (1.79998842375 Å)