7DOK

Structure of COVID-19 RNA-dependent RNA polymerase (extended conformation) bound to penciclovir

Summary for 7DOK

• Entry DOI: 10.2210/pdb7dok/pdb
• EMDB information: 30663 30664 30794 30795
• Descriptor: RNA (5'-R(P*GP*CP*UP*AP*UP*GP*UP*GP*AP*GP*AP*UP*UP*AP*AP*GP*UP*UP*AP*U)-3'), RNA (5'-R(P*CP*CP*CP*UP*AP*UP*AP*AP*CP*UP*UP*AP*AP*UP*CP*UP*CP*AP*CP*AP*UP*AP*GP*C)-3'), RNA-directed RNA polymerase, ... (10 entities in total)
• Functional Keywords: covid-19, rna polymerase in extended conformation, penciclovir binding, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); More
• Total number of polymer chains: 6
• Total formula weight: 176256.25

Authors

Li, Z.,Yu, X. (deposition date: 2020-12-14, release date: 2021-12-15, Last modification date: 2024-06-05)

• Primary citation: Yin, W.,Luan, X.,Li, Z.,Xie, Y.,Zhou, Z.,Liu, J.,Gao, M.,Wang, X.,Zhou, F.,Wang, Q.,Wang, Q.,Shen, D.,Zhang, Y.,Tian, G.,Aisa, H.,Wei, D.,Jiang, Y.,Xiao, G.,Jiang, H.,Zhang, L.,Yu, X.,Shen, J.,Zhang, S.,Xu, H.; Structural basis for repurpose and design of nucleotide drugs for treating COVID-19; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.73 Å)