7DOK

Structure of COVID-19 RNA-dependent RNA polymerase (extended conformation) bound to penciclovir

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	P	RNA (5'-R(P*GP*CP*UP*AP*UP*GP*UP*GP*AP*GP*AP*UP*UP*AP*AP*GP*UP*UP*AP*U)-3')	polymer	20	6410.8	1		Severe acute respiratory syndrome coronavirus 2
2	T	RNA (5'-R(P*CP*CP*CP*UP*AP*UP*AP*AP*CP*UP*UP*AP*AP*UP*CP*UP*CP*AP*CP*AP*UP*AP*GP*C)-3')	polymer	24	7518.5	1		Severe acute respiratory syndrome coronavirus 2
3	A	RNA-directed RNA polymerase	polymer	943	107965.3	1	UniProt (P0DTD1) Pfam (PF06478) Pfam (PF00680) In PDB	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)	Non-structural protein 12
4	B, G	Non-structural protein 8	polymer	199	22034.2	2	UniProt (P0DTD1) Pfam (PF08717) In PDB	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
5	C	Non-structural protein 7	polymer	84	9380.0	1	UniProt (P0DTD1) Pfam (PF08716) In PDB	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
6	P	[(2R)-4-(2-azanyl-6-oxidanylidene-3H-purin-9-yl)-2-(hydroxymethyl)butyl] dihydrogen phosphate	non-polymer		333.2	1	Chemie (HCU)
7	P, A	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
8	A	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
9	A	PYROPHOSPHATE 2-	non-polymer		176.0	2	Chemie (POP)
10		water	water		18.0	2	Chemie (HOH)

Sequence modifications

A: 1 - 932 (UniProt: P0DTD1)

PDB	External Database	Details
Met 0	-	initiating methionine
Gly 933	-	expression tag
Gly 934	-	expression tag
Ser 935	-	expression tag
Glu 936	-	expression tag
Asn 937	-	expression tag
Leu 938	-	expression tag
Tyr 939	-	expression tag
Phe 940	-	expression tag
Gln 941	-	expression tag
Gly 942	-	expression tag

B, G: 1 - 198 (UniProt: P0DTD1)

PDB	External Database	Details
Met 0	-	initiating methionine

C: 1 - 83 (UniProt: P0DTD1)

PDB	External Database	Details
Met 0	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	175343.1
Non-Polymers*	Number of molecules	9
	Total formula weight	913.2
All*	Total formula weight	176256.3

*Water molecules are not included.