7DNE

DARPin 5m3_D12 in complex with V3-IY (MN) crown mimetic

Summary for 7DNE

Entry DOI	10.2210/pdb7dne/pdb
Descriptor	DARPin 5m3_D12, V3-IY (MN) crown mimetic peptide (3 entities in total)
Functional Keywords	designed ankyrin repeat proteins, protein design, protein engineering, anti-hiv, de novo protein
Biological source	synthetic construct More
Total number of polymer chains	4
Total formula weight	37089.78
Authors	Wu, Y.,Plueckthun, A. (deposition date: 2020-12-09, release date: 2021-12-22, Last modification date: 2023-11-29)
Primary citation	Friedrich, N.,Stiegeler, E.,Glogl, M.,Lemmin, T.,Hansen, S.,Kadelka, C.,Wu, Y.,Ernst, P.,Maliqi, L.,Foulkes, C.,Morin, M.,Eroglu, M.,Liechti, T.,Ivan, B.,Reinberg, T.,Schaefer, J.V.,Karakus, U.,Ursprung, S.,Mann, A.,Rusert, P.,Kouyos, R.D.,Robinson, J.A.,Gunthard, H.F.,Pluckthun, A.,Trkola, A. Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization. Nat Commun, 12:6705-6705, 2021 Cited by PubMed: 34795280 DOI: 10.1038/s41467-021-27075-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation