7DMY

The crystal structure of Cpd7 in complex with BPTF bromodomain

7DMY の概要

• エントリーDOI: 10.2210/pdb7dmy/pdb
• 分子名称: Nucleosome-remodeling factor subunit BPTF, tert-butyl 3-methyl-2-[[(3R,5R)-1-methyl-5-phenyl-piperidin-3-yl]amino]-4-oxidanylidene-5,7-dihydropyrrolo[3,4-d]pyrimidine-6-carboxylate (3 entities in total)
• 機能のキーワード: inhibitor;bptf;bromodomain, protein binding
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17366.64

構造登録者

Xiong, L.,Guo, Y.,Yang, S. (登録日: 2020-12-08, 公開日: 2021-10-20, 最終更新日: 2023-11-29)

• 主引用文献: Xiong, L.,Mao, X.,Guo, Y.,Zhou, Y.,Chen, M.,Chen, P.,Yang, S.,Li, L.; Discovery of selective BPTF bromodomain inhibitors by screening and structure-based optimization.; Biochem.Biophys.Res.Commun., 545:125-131, 2021; PubMed: 33548625; DOI: 10.1016/j.bbrc.2021.01.067

実験手法

X-RAY DIFFRACTION (2 Å)