7DKM

PHGDH covalently linked to oridonin

7DKM の概要

• エントリーDOI: 10.2210/pdb7dkm/pdb
• 分子名称: D-3-phosphoglycerate dehydrogenase, (1beta,6beta,7beta,8alpha,9beta,10alpha,13alpha,14R,16beta)-1,6,7,14-tetrahydroxy-7,20-epoxykauran-15-one, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (7 entities in total)
• 機能のキーワード: inhibitor, complex, dehydrogenase, covalent, oxidoreductase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 69967.63

構造登録者

Sun, Q.,Lei, Y. (登録日: 2020-11-25, 公開日: 2022-02-02, 最終更新日: 2023-11-29)

• 主引用文献: Tan, Y.,Zhou, X.,Gong, Y.,Gou, K.,Luo, Y.,Jia, D.,Dai, L.,Zhao, Y.,Sun, Q.; Biophysical and biochemical properties of PHGDH revealed by studies on PHGDH inhibitors.; Cell.Mol.Life Sci., 79:27-27, 2021; PubMed: 34971423; DOI: 10.1007/s00018-021-04022-2

実験手法

X-RAY DIFFRACTION (1.7 Å)