7DHZ
Arsenic-bound p53 DNA-binding domain mutant R249S
Summary for 7DHZ
Entry DOI | 10.2210/pdb7dhz/pdb |
Descriptor | Cellular tumor antigen p53, GLYCEROL, ARSENIC, ... (5 entities in total) |
Functional Keywords | tumour suppressor, transcription factor, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 45427.88 |
Authors | |
Primary citation | Chen, S.,Wu, J.L.,Liang, Y.,Tang, Y.G.,Song, H.X.,Wu, L.L.,Xing, Y.F.,Yan, N.,Li, Y.T.,Wang, Z.Y.,Xiao, S.J.,Lu, X.,Chen, S.J.,Lu, M. Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site. Cancer Cell, 39:225-239.e8, 2021 Cited by PubMed: 33357454DOI: 10.1016/j.ccell.2020.11.013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.74 Å) |
Structure validation
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