7DHZ

Arsenic-bound p53 DNA-binding domain mutant R249S

Summary for 7DHZ

• Entry DOI: 10.2210/pdb7dhz/pdb
• Descriptor: Cellular tumor antigen p53, GLYCEROL, ARSENIC, ... (5 entities in total)
• Functional Keywords: tumour suppressor, transcription factor, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 45427.88

Authors

Chen, S.,Lu, M. (deposition date: 2020-11-18, release date: 2021-03-03, Last modification date: 2023-11-29)

• Primary citation: Chen, S.,Wu, J.L.,Liang, Y.,Tang, Y.G.,Song, H.X.,Wu, L.L.,Xing, Y.F.,Yan, N.,Li, Y.T.,Wang, Z.Y.,Xiao, S.J.,Lu, X.,Chen, S.J.,Lu, M.; Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site.; Cancer Cell, 39:225-239.e8, 2021; PubMed: 33357454; DOI: 10.1016/j.ccell.2020.11.013

Experimental method

X-RAY DIFFRACTION (1.74 Å)