7DHR

Cryo-EM structure of the full agonist isoprenaline-bound beta2 adrenergic receptor-Gs protein complex.

7DHR の概要

• エントリーDOI: 10.2210/pdb7dhr/pdb
• EMDBエントリー: 30682
• 分子名称: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• 機能のキーワード: g protein coupled receptor, isoprenaline, complex, cryo-em, signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 151259.04

構造登録者

Yang, F.,Ling, S.L.,Zhou, Y.X.,Zhang, Y.N.,Lv, P.,Liu, S.L.,Fang, W.,Sun, W.J.,Hu, L.Y.A. (登録日: 2020-11-17, 公開日: 2020-12-16)

• 主引用文献: Yang, F.,Ling, S.L.,Zhou, Y.X.,Zhang, Y.N.,Lv, P.,Liu, S.L.,Fang, W.,Sun, W.J.,Hu, L.Y.A.,Zhang, L.,Shi, P.,Tian, C.; Different Conformational Responses of the beta2-Adrenergic Receptor-Gs Complex upon Binding of the Partial Agonist Salbutamol or the Full Agonist Isoprenaline; Natl Sci Rev, 2020; DOI: 10.1093/nsr/nwaa284

実験手法

ELECTRON MICROSCOPY (3.8 Å)