7D9T

Structure of human soluble guanylate cyclase in the cinciguat-bound inactive state

Summary for 7D9T

• Entry DOI: 10.2210/pdb7d9t/pdb
• EMDB information: 30620
• Descriptor: Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid (3 entities in total)
• Functional Keywords: soluble guanylate cyclase, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 148731.50

Authors

Chen, L.,Liu, R.,Kang, Y. (deposition date: 2020-10-14, release date: 2021-08-11, Last modification date: 2024-05-29)

• Primary citation: Liu, R.,Kang, Y.,Chen, L.; Activation mechanism of human soluble guanylate cyclase by stimulators and activators.; Nat Commun, 12:5492-5492, 2021; PubMed: 34535643; DOI: 10.1038/s41467-021-25617-0

Experimental method

ELECTRON MICROSCOPY (4.1 Å)