7D8X
CryoEM structure of human gamma-secretase in complex with E2012 and L685458
Summary for 7D8X
Entry DOI | 10.2210/pdb7d8x/pdb |
EMDB information | 30614 |
Descriptor | Nicastrin, PHOSPHATIDYLETHANOLAMINE, ~{tert}-butyl ~{N}-[(2~{S},3~{R},5~{R})-6-[[(2~{S})-1-[[(2~{S})-1-azanyl-1-oxidanylidene-3-phenyl-propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]amino]-3-oxidanyl-6-oxidanylidene-1-phenyl-5-(phenylmethyl)hexan-2-yl]carbamate, ... (12 entities in total) |
Functional Keywords | inhibitor, modulator, membrane protein, hydrolase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 185640.44 |
Authors | |
Primary citation | Yang, G.,Zhou, R.,Guo, X.,Yan, C.,Lei, J.,Shi, Y. Structural basis of gamma-secretase inhibition and modulation by small molecule drugs. Cell, 184:521-533.e14, 2021 Cited by PubMed: 33373587DOI: 10.1016/j.cell.2020.11.049 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.6 Å) |
Structure validation
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