7D8B

Engineering Disulphide-Free Autonomous Antibody VH Domains to modulate intracellular pathways

Summary for 7D8B

• Entry DOI: 10.2210/pdb7d8b/pdb
• Descriptor: Eukaryotic translation initiation factor 4E, VH-S4 (3 entities in total)
• Functional Keywords: cap dependent translation, complex, vh domain, rna binding protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 84554.20

Authors

Frosi, Y.,Lin, Y.C.,Jiang, S.,Brown, C.J. (deposition date: 2020-10-07, release date: 2021-08-25, Last modification date: 2023-11-29)

• Primary citation: Frosi, Y.,Lin, Y.C.,Shimin, J.,Ramlan, S.R.,Hew, K.,Engman, A.H.,Pillai, A.,Yeung, K.,Cheng, Y.X.,Cornvik, T.,Nordlund, P.,Goh, M.,Lama, D.,Gates, Z.P.,Verma, C.S.,Thean, D.,Lane, D.P.,Asial, I.,Brown, C.J.; Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex.; Nat Commun, 13:4854-4854, 2022; PubMed: 35982046; DOI: 10.1038/s41467-022-32463-1

Experimental method

X-RAY DIFFRACTION (2.46 Å)