7E35
Crystal structure of the SARS-CoV-2 papain-like protease (PLPro) C112S mutant bound to compound S43
Replaces: 7D7TSummary for 7E35
Entry DOI | 10.2210/pdb7e35/pdb |
Related | 7D6H |
Descriptor | Non-structural protein 3, ZINC ION, N-[(3-acetamidophenyl)methyl]-1-[(1R)-1-naphthalen-1-ylethyl]piperidine-4-carboxamide (3 entities in total) |
Functional Keywords | protease, deubiquitinase, viral protein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) |
Total number of polymer chains | 2 |
Total formula weight | 72300.80 |
Authors | |
Primary citation | Shan, H.,Liu, J.,Shen, J.,Dai, J.,Xu, G.,Lu, K.,Han, C.,Wang, Y.,Xu, X.,Tong, Y.,Xiang, H.,Ai, Z.,Zhuang, G.,Hu, J.,Zhang, Z.,Li, Y.,Pan, L.,Tan, L. Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2. Cell Chem Biol, 28:855-, 2021 Cited by PubMed: 33979649DOI: 10.1016/j.chembiol.2021.04.020 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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