7D6G

Neutron crystal Structure of E.coli Dihydrofolate Reductase complexed with folate and NADP+ at pH4.5

Summary for 7D6G

• Entry DOI: 10.2210/pdb7d6g/pdb
• Descriptor: Dihydrofolate reductase, MANGANESE (II) ION, FOLIC ACID, ... (5 entities in total)
• Functional Keywords: alpha beta alpha sandwich, oxidoreductase
• Biological source: Escherichia coli (strain K12)
• Total number of polymer chains: 1
• Total formula weight: 19259.08

Authors

Wan, Q.,Dealwis, C. (deposition date: 2020-09-30, release date: 2021-06-09, Last modification date: 2024-04-03)

• Primary citation: Wan, Q.,Bennett, B.C.,Wymore, T.,Li, Z.,Wilson, M.A.,Brooks III, C.L.,Langan, P.,Kovalevsky, A.,Dealwis, C.G.; Capturing the Catalytic Proton of Dihydrofolate Reductase: Implications for General Acid-Base Catalysis; Acs Catalysis, 11:5873-5884, 2021; DOI: 10.1021/acscatal.1c00417

Experimental method

NEUTRON DIFFRACTION (2.1 Å)
X-RAY DIFFRACTION (1.65 Å)