7D5E

Left-handed G-quadruplex containing two bulges

7D5E の概要

• エントリーDOI: 10.2210/pdb7d5e/pdb
• 分子名称: 2xBulge-LHG4motif, POTASSIUM ION, SPERMINE, ... (5 entities in total)
• 機能のキーワード: g-quadruplex, bulge, dna, left-handed
• 由来する生物種: synthetic construct
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 18851.33

構造登録者

Das, P.,Maity, A.,Ngo, K.H.,Winnerdy, F.R.,Bakalar, B.,Mechulam, Y.,Schmitt, E.,Phan, A.T. (登録日: 2020-09-25, 公開日: 2021-02-10, 最終更新日: 2023-11-29)

主引用文献

Das, P.,Ngo, K.H.,Winnerdy, F.R.,Maity, A.,Bakalar, B.,Mechulam, Y.,Schmitt, E.,Phan, A.T.
Bulges in left-handed G-quadruplexes.
Nucleic Acids Res., 49:1724-1736, 2021

PubMed Abstract: G-quadruplex (G4) DNA structures with a left-handed backbone progression have unique and conserved structural features. Studies on sequence dependency of the structures revealed the prerequisites and some minimal motifs required for left-handed G4 formation. To extend the boundaries, we explore the adaptability of left-handed G4s towards the existence of bulges. Here we present two X-ray crystal structures and an NMR solution structure of left-handed G4s accommodating one, two and three bulges. Bulges in left-handed G4s show distinct characteristics as compared to those in right-handed G4s. The elucidation of intricate structural details will help in understanding the possible roles and limitations of these unique structures.

PubMed: 33503265
DOI: 10.1093/nar/gkaa1259

実験手法

X-RAY DIFFRACTION (1.296 Å)