7D5C

IleRS in complex with a tRNA site inhibitor

Summary for 7D5C

• Entry DOI: 10.2210/pdb7d5c/pdb
• Descriptor: Isoleucine--tRNA ligase, cytoplasmic, (2E,4S,5S,6E,8E)-10-[(2S,3R,6S,8R,9S)-3-butyl-9-methyl-2-[(1E,3E)-3-methyl-5-oxidanyl-5-oxidanylidene-penta-1,3-dienyl]-3-(4-oxidanyl-4-oxidanylidene-butanoyl)oxy-1,7-dioxaspiro[5.5]undecan-8-yl]-4,8-dimethyl-5-oxidanyl-deca-2,6,8-trienoic acid, [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] (2S,3S)-2-azanyl-3-methyl-pentanoate, ... (5 entities in total)
• Functional Keywords: trna synthetase, ligase-inhibitor complex, ligase/inhibitor
• Biological source: Saccharomyces cerevisiae S288c (Baker's yeast)
• Total number of polymer chains: 1
• Total formula weight: 115414.30

Authors

Chen, B.,Luo, S.,Zhou, H. (deposition date: 2020-09-25, release date: 2021-02-24, Last modification date: 2023-11-29)

• Primary citation: Chen, B.,Luo, S.,Zhang, S.,Ju, Y.,Gu, Q.,Xu, J.,Yang, X.L.,Zhou, H.; Inhibitory mechanism of reveromycin A at the tRNA binding site of a class I synthetase.; Nat Commun, 12:1616-1616, 2021; PubMed: 33712620; DOI: 10.1038/s41467-021-21902-0

Experimental method

X-RAY DIFFRACTION (1.895 Å)