7D4F

Structure of COVID-19 RNA-dependent RNA polymerase bound to suramin

Summary for 7D4F

• Entry DOI: 10.2210/pdb7d4f/pdb
• EMDB information: 30572
• Descriptor: Non-structural protein 8, Non-structural protein 7, RNA-directed RNA polymerase, ... (5 entities in total)
• Functional Keywords: covid-19, rna polymerase, suramin binding, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); More
• Total number of polymer chains: 4
• Total formula weight: 162815.84

Authors

Li, Z.,Yin, W.,Zhou, Z.,Yu, X.,Xu, H. (deposition date: 2020-09-23, release date: 2020-11-11, Last modification date: 2024-03-27)

• Primary citation: Yin, W.,Luan, X.,Li, Z.,Zhou, Z.,Wang, Q.,Gao, M.,Wang, X.,Zhou, F.,Shi, J.,You, E.,Liu, M.,Wang, Q.,Jiang, Y.,Jiang, H.,Xiao, G.,Zhang, L.,Yu, X.,Zhang, S.,Eric Xu, H.; Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin.; Nat.Struct.Mol.Biol., 28:319-325, 2021; PubMed: 33674802; DOI: 10.1038/s41594-021-00570-0

Experimental method

ELECTRON MICROSCOPY (2.57 Å)