7D12

NMR solution structures of CAG RNA-DB213 binding complex

Summary for 7D12

• Entry DOI: 10.2210/pdb7d12/pdb
• Descriptor: RNA (5'-R(*GP*CP*AP*GP*CP*AP*GP*CP*UP*UP*CP*GP*GP*CP*AP*GP*CP*AP*GP*C)-3'), N'-{(Z)-amino[4-(amino{[3-(dimethylammonio)propyl]iminio}methyl)phenyl]methylidene}-N,N-dimethylpropane-1,3-diaminium, SODIUM ION (3 entities in total)
• Functional Keywords: rna, cag rna, ligand, complex
• Biological source: Homo sapiens
• Total number of polymer chains: 1
• Total formula weight: 7118.28

Authors

Chan, H.Y.E.,Guo, P. (deposition date: 2020-09-12, release date: 2021-05-12, Last modification date: 2024-05-01)

• Primary citation: Peng, S.,Guo, P.,Lin, X.,An, Y.,Sze, K.H.,Lau, M.H.Y.,Chen, Z.S.,Wang, Q.,Li, W.,Sun, J.K.,Ma, S.Y.,Chan, T.F.,Lau, K.F.,Ngo, J.C.K.,Kwan, K.M.,Wong, C.H.,Lam, S.L.,Zimmerman, S.C.,Tuccinardi, T.,Zuo, Z.,Au-Yeung, H.Y.,Chow, H.M.,Chan, H.Y.E.; CAG RNAs induce DNA damage and apoptosis by silencing NUDT16 expression in polyglutamine degeneration.; Proc.Natl.Acad.Sci.USA, 118:-, 2021; PubMed: 33947817; DOI: 10.1073/pnas.2022940118

Experimental method

SOLUTION NMR