7CYQ

Cryo-EM structure of an extended SARS-CoV-2 replication and transcription complex reveals an intermediate state in cap synthesis

7CYQ の概要

• エントリーDOI: 10.2210/pdb7cyq/pdb
• EMDBエントリー: 30504
• 分子名称: RNA-directed RNA polymerase, MAGNESIUM ION, Non-structural protein 8, ... (10 entities in total)
• 機能のキーワード: sars-cov-2, transcription and replication, nsp9, nsp13, nsp12-nsp7-nsp8, viral protein-rna complex, viral protein/rna
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); 詳細
• タンパク質・核酸の鎖数: 9
• 化学式量合計: 338376.40

構造登録者

Yan, L.,Ge, J.,Zheng, L.,Zhang, Y.,Gao, Y.,Wang, T.,Wang, H.,Huang, Y.,Li, M.,Wang, Q.,Rao, Z.,Lou, Z. (登録日: 2020-09-04, 公開日: 2020-12-09, 最終更新日: 2024-03-27)

• 主引用文献: Yan, L.,Ge, J.,Zheng, L.,Zhang, Y.,Gao, Y.,Wang, T.,Huang, Y.,Yang, Y.,Gao, S.,Li, M.,Liu, Z.,Wang, H.,Li, Y.,Chen, Y.,Guddat, L.W.,Wang, Q.,Rao, Z.,Lou, Z.; Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis.; Cell, 184:184-193.e10, 2021; PubMed: 33232691; DOI: 10.1016/j.cell.2020.11.016

実験手法

ELECTRON MICROSCOPY (2.83 Å)