7CX4

Cryo-EM structure of the Evatanepag-bound EP2-Gs complex

7CX4 の概要

• エントリーDOI: 10.2210/pdb7cx4/pdb
• EMDBエントリー: 30491
• 分子名称: Prostaglandin E2 receptor EP2 subtype, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (6 entities in total)
• 機能のキーワード: gpcr, ep2, complex, evatanepag, membrane protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 147188.17

構造登録者

Qu, C.,Mao, C.,Xiao, P.,Shen, Q.,Zhong, Y.,Yang, F.,Shen, D.,Tao, X.,Zhang, H.,Yan, X.,Zhao, R.,He, J.,Guan, Y.,Zhang, C.,Hou, G.,Zhang, P.,Yu, X.,Guan, Y.,Sun, J.,Zhang, Y. (登録日: 2020-09-01, 公開日: 2021-05-05)

• 主引用文献: Qu, C.,Mao, C.,Xiao, P.,Shen, Q.,Zhong, Y.N.,Yang, F.,Shen, D.D.,Tao, X.,Zhang, H.,Yan, X.,Zhao, R.J.,He, J.,Guan, Y.,Zhang, C.,Hou, G.,Zhang, P.J.,Hou, G.,Li, Z.,Yu, X.,Chai, R.J.,Guan, Y.F.,Sun, J.P.,Zhang, Y.; Ligand recognition, unconventional activation, and G protein coupling of the prostaglandin E 2 receptor EP2 subtype.; Sci Adv, 7:-, 2021; PubMed: 33811074; DOI: 10.1126/sciadv.abf1268

実験手法

ELECTRON MICROSCOPY (2.9 Å)