7CVN

The N-arylsulfonyl-indole-2-carboxamide-based inhibitors against fructose-1,6-bisphosphatase

7CVN の概要

• エントリーDOI: 10.2210/pdb7cvn/pdb
• 分子名称: Fructose-1,6-bisphosphatase 1, 4-(3-acetamidophenyl)-N-(4-methoxyphenyl)sulfonyl-7-nitro-1H-indole-2-carboxamide, 1,6-di-O-phosphono-beta-D-fructofuranose, ... (4 entities in total)
• 機能のキーワード: fructose-1, 6-bisphosphatase, n-arylsulfonyl-indole-2-carboxamide, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 150944.21

構造登録者

Wang, X.,Zhou, J.,Xu, B. (登録日: 2020-08-26, 公開日: 2020-09-23, 最終更新日: 2023-11-29)

• 主引用文献: Bie, J.,Wang, X.,Liu, S.,Zhou, J.,Liu, Q.,Shen, Z.,Xu, B.; Design,synthesis,biological evaluation and binding mode analysis of 7-nitro-indole-N-acylarylsulfonamide-based fructose-1,6-bisphosphatase inhibitors; Chinese journal of medicinal chemistry, 30:713-724, 2020; DOI: 10.14142/j.cnki.cn21-1313/r.2020.12.001

実験手法

X-RAY DIFFRACTION (2.75 Å)