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7CUM

Cryo-EM structure of human GABA(B) receptor bound to the antagonist CGP54626

Summary for 7CUM
Entry DOI10.2210/pdb7cum/pdb
EMDB information30323 30324 30472
DescriptorGamma-aminobutyric acid type B receptor subunit 1, Gamma-aminobutyric acid type B receptor subunit 2, (R)-(cyclohexylmethyl)[(2S)-3-{[(1S)-1-(3,4-dichlorophenyl)ethyl]amino}-2-hydroxypropyl]phosphinic acid, ... (5 entities in total)
Functional Keywordsgpcr, gaba, neurosignalling, signaling protein, membrane protein
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains2
Total formula weight187702.55
Authors
Kim, Y.,Jeong, E.,Jeong, J.,Kim, Y.,Cho, Y. (deposition date: 2020-08-23, release date: 2020-11-11)
Primary citationKim, Y.,Jeong, E.,Jeong, J.H.,Kim, Y.,Cho, Y.
Structural Basis for Activation of the Heterodimeric GABA B Receptor.
J.Mol.Biol., 432:5966-5984, 2020
Cited by
PubMed: 33058878
DOI: 10.1016/j.jmb.2020.09.023
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (3.52 Å)
Structure validation

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