7CTZ

Wild-type plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with fragment 148, NADPH, and dUMP

Summary for 7CTZ

• Entry DOI: 10.2210/pdb7ctz/pdb
• Descriptor: Bifunctional dihydrofolate reductase-thymidylate synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ... (5 entities in total)
• Functional Keywords: anti-folate, anti-malarial, plasmodium falciparum, dihydrofolate reductase, antibiotic, oxidoreductase
• Biological source: Plasmodium falciparum (malaria parasite P. falciparum)
• Total number of polymer chains: 2
• Total formula weight: 145967.36

Authors

Vitsupakorn, D. (deposition date: 2020-08-20, release date: 2022-02-23, Last modification date: 2023-11-29)

• Primary citation: Hoarau, M.,Vanichtanankul, J.,Srimongkolpithak, N.,Vitsupakorn, D.,Yuthavong, Y.,Kamchonwongpaisan, S.; Discovery of new non-pyrimidine scaffolds as Plasmodium falciparum DHFR inhibitors by fragment-based screening.; J Enzyme Inhib Med Chem, 36:198-206, 2021; PubMed: 33530764; DOI: 10.1080/14756366.2020.1854244

Experimental method

X-RAY DIFFRACTION (2.65 Å)