7CTY

Wild type plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS), fragment 263, NADP+, dUMP

7CTY の概要

• エントリーDOI: 10.2210/pdb7cty/pdb
• 分子名称: Bifunctional dihydrofolate reductase-thymidylate synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, spiro[1H-2-benzofuran-3,4'-piperidine], ... (5 entities in total)
• 機能のキーワード: dihydrofolate reductase, plasmodium falciparum, antimalarial, antifolate, fragment, antibiotic, oxidoreductase
• 由来する生物種: Plasmodium falciparum (malaria parasite P. falciparum)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 144969.87

構造登録者

Vanichtanankul, J.,Vitsupakorn, D. (登録日: 2020-08-20, 公開日: 2021-03-31, 最終更新日: 2023-11-29)

• 主引用文献: Hoarau, M.,Vanichtanankul, J.,Srimongkolpithak, N.,Vitsupakorn, D.,Yuthavong, Y.,Kamchonwongpaisan, S.; Discovery of new non-pyrimidine scaffolds as Plasmodium falciparum DHFR inhibitors by fragment-based screening.; J Enzyme Inhib Med Chem, 36:198-206, 2021; PubMed: 33530764; DOI: 10.1080/14756366.2020.1854244

実験手法

X-RAY DIFFRACTION (2.8 Å)