7CRQ

NSD3 bearing E1181K/T1232A dual mutation in complex with 187-bp NCP (2:1 binding mode)

Summary for 7CRQ

• Entry DOI: 10.2210/pdb7crq/pdb
• Related: 7CRO 7CRP
• EMDB information: 30453 30454 30455 30456
• Descriptor: Histone H3, Histone H4, Histone H2A, ... (9 entities in total)
• Functional Keywords: nucleosome complex, histone methyltransferase, dna, gene reguration, gene regulation
• Biological source: Xenopus laevis (African clawed frog); More
• Total number of polymer chains: 12
• Total formula weight: 395549.52

Authors

Li, W.,Tian, W.,Yuan, G.,Deng, P.,Gozani, O.,Patel, D.,Wang, Z. (deposition date: 2020-08-14, release date: 2020-10-21, Last modification date: 2021-03-03)

• Primary citation: Li, W.,Tian, W.,Yuan, G.,Deng, P.,Sengupta, D.,Cheng, Z.,Cao, Y.,Ren, J.,Qin, Y.,Zhou, Y.,Jia, Y.,Gozani, O.,Patel, D.J.,Wang, Z.; Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases.; Nature, 590:498-503, 2021; PubMed: 33361816; DOI: 10.1038/s41586-020-03069-8

Experimental method

ELECTRON MICROSCOPY (3.15 Å)