7CQE

Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with AZD-7762

Summary for 7CQE

Entry DOI	10.2210/pdb7cqe/pdb
Descriptor	Tyrosine-protein kinase Mer, CHLORIDE ION, 5-(3-fluorophenyl)-N-[(3S)-3-piperidyl]-3-ureido-thiophene-2-carboxamide, ... (4 entities in total)
Functional Keywords	transferase inhibitor, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	68650.02
Authors	Park, T.H.,Lee, B.I. (deposition date: 2020-08-10, release date: 2020-11-04, Last modification date: 2023-11-29)
Primary citation	Park, T.H.,Bae, S.H.,Bong, S.M.,Ryu, S.E.,Jang, H.,Lee, B.I. Crystal Structure of the Kinase Domain of MerTK in Complex with AZD7762 Provides Clues for Structure-Based Drug Development. Int J Mol Sci, 21:-, 2020 Cited by PubMed: 33114206 DOI: 10.3390/ijms21217878 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.69 Å)

Structure validation