7CQE
Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with AZD-7762
Summary for 7CQE
Entry DOI | 10.2210/pdb7cqe/pdb |
Descriptor | Tyrosine-protein kinase Mer, CHLORIDE ION, 5-(3-fluorophenyl)-N-[(3S)-3-piperidyl]-3-ureido-thiophene-2-carboxamide, ... (4 entities in total) |
Functional Keywords | transferase inhibitor, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 68650.02 |
Authors | Park, T.H.,Lee, B.I. (deposition date: 2020-08-10, release date: 2020-11-04, Last modification date: 2023-11-29) |
Primary citation | Park, T.H.,Bae, S.H.,Bong, S.M.,Ryu, S.E.,Jang, H.,Lee, B.I. Crystal Structure of the Kinase Domain of MerTK in Complex with AZD7762 Provides Clues for Structure-Based Drug Development. Int J Mol Sci, 21:-, 2020 Cited by PubMed: 33114206DOI: 10.3390/ijms21217878 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.69 Å) |
Structure validation
Download full validation report