7CQE

Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with AZD-7762

7CQE の概要

• エントリーDOI: 10.2210/pdb7cqe/pdb
• 分子名称: Tyrosine-protein kinase Mer, CHLORIDE ION, 5-(3-fluorophenyl)-N-[(3S)-3-piperidyl]-3-ureido-thiophene-2-carboxamide, ... (4 entities in total)
• 機能のキーワード: transferase inhibitor, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68650.02

構造登録者

Park, T.H.,Lee, B.I. (登録日: 2020-08-10, 公開日: 2020-11-04, 最終更新日: 2023-11-29)

• 主引用文献: Park, T.H.,Bae, S.H.,Bong, S.M.,Ryu, S.E.,Jang, H.,Lee, B.I.; Crystal Structure of the Kinase Domain of MerTK in Complex with AZD7762 Provides Clues for Structure-Based Drug Development.; Int J Mol Sci, 21:-, 2020; PubMed: 33114206; DOI: 10.3390/ijms21217878

実験手法

X-RAY DIFFRACTION (2.69 Å)