7CNN

vinorelbine in complex with tubulin

Summary for 7CNN

• Entry DOI: 10.2210/pdb7cnn/pdb
• Descriptor: Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Vinorelbine, ... (12 entities in total)
• Functional Keywords: vincristinve, tubulin, protein-drug complex, cell cycle
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 6
• Total formula weight: 265130.76

Authors

Wang, Y.X.,Wu, C.Y. (deposition date: 2020-08-02, release date: 2021-08-04, Last modification date: 2023-11-29)

• Primary citation: Chengyong, W.,Jinghong, X.,Yanyan, W.,Qing-Jie, X.,Lingling, M.,Yuyan, L.,Hai, C.,Qian, L.,Quan, Z.,Bo, S.,Yuxi, W.; The high-resolution X-ray structure of vinca-domain inhibitors of microtubules provides a rational approach for drug design.; Febs Lett., 595:195-205, 2021; PubMed: 33220079; DOI: 10.1002/1873-3468.14003

Experimental method

X-RAY DIFFRACTION (2.5 Å)