7CNN
vinorelbine in complex with tubulin
Summary for 7CNN
Entry DOI | 10.2210/pdb7cnn/pdb |
Descriptor | Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Vinorelbine, ... (12 entities in total) |
Functional Keywords | vincristinve, tubulin, protein-drug complex, cell cycle |
Biological source | Mus musculus (Mouse) More |
Total number of polymer chains | 6 |
Total formula weight | 265130.76 |
Authors | Wang, Y.X.,Wu, C.Y. (deposition date: 2020-08-02, release date: 2021-08-04, Last modification date: 2023-11-29) |
Primary citation | Chengyong, W.,Jinghong, X.,Yanyan, W.,Qing-Jie, X.,Lingling, M.,Yuyan, L.,Hai, C.,Qian, L.,Quan, Z.,Bo, S.,Yuxi, W. The high-resolution X-ray structure of vinca-domain inhibitors of microtubules provides a rational approach for drug design. Febs Lett., 595:195-205, 2021 Cited by PubMed: 33220079DOI: 10.1002/1873-3468.14003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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