7CNM

YDX in complex with tubulin

7CNM の概要

• エントリーDOI: 10.2210/pdb7cnm/pdb
• 分子名称: Tubulin alpha-1B chain, (2~{S},4~{S})-4-[[2-[(1~{R},3~{R})-1-acetyloxy-4-methyl-3-[[(2~{S},3~{S})-3-methyl-2-[[(2~{R})-1-methylpiperidin-2-yl]carbonylamino]pentanoyl]amino]pentyl]-1,3-thiazol-4-yl]carbonylamino]-5-cyclohexyl-2-methyl-pentanoic acid, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total)
• 機能のキーワード: ydx, tubulin, protein-drug complex, cell cycle
• 由来する生物種: Mus musculus (Mouse); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 266248.02

構造登録者

Wang, Y.X.,Wu, C.Y. (登録日: 2020-08-02, 公開日: 2021-08-04, 最終更新日: 2023-11-29)

• 主引用文献: Chengyong, W.,Jinghong, X.,Yanyan, W.,Qing-Jie, X.,Lingling, M.,Yuyan, L.,Hai, C.,Qian, L.,Quan, Z.,Bo, S.,Yuxi, W.; The high-resolution X-ray structure of vinca-domain inhibitors of microtubules provides a rational approach for drug design.; Febs Lett., 595:195-205, 2021; PubMed: 33220079; DOI: 10.1002/1873-3468.14003

実験手法

X-RAY DIFFRACTION (2.44 Å)