7CNL
Crystal structure of TEAD3 in complex with VT105
Summary for 7CNL
Entry DOI | 10.2210/pdb7cnl/pdb |
Descriptor | Transcriptional enhancer factor TEF-5, N-oxidanyltetradecanamide, PHOSPHATE ION, ... (7 entities in total) |
Functional Keywords | tead, inhibitor, palmitoylation, hippo pathway, dna binding protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 103816.69 |
Authors | Tang, T.T.,Konradi, A.W. (deposition date: 2020-08-01, release date: 2021-04-28, Last modification date: 2023-11-29) |
Primary citation | Tang, T.T.,Konradi, A.W.,Feng, Y.,Peng, X.,Ma, M.,Li, J.,Yu, F.X.,Guan, K.L.,Post, L. Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2 -deficient Mesothelioma. Mol.Cancer Ther., 20:986-998, 2021 Cited by PubMed: 33850002DOI: 10.1158/1535-7163.MCT-20-0717 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
Download full validation report