7CLY

Structure of the DOCK8 DHR-1 domain crystallized with di-C8-phosphatidylinositol-(4,5)-bisphosphate

Summary for 7CLY

• Entry DOI: 10.2210/pdb7cly/pdb
• Related: 7CLX
• Descriptor: Dedicator of cytokinesis protein 8 (2 entities in total)
• Functional Keywords: dock, guanine nucleotide exchange factor, gtpase, cdc42, membrane, di-c8-pi(4, 5)p2, phosphoinositide, signaling protein
• Biological source: Mus musculus (Mouse)
• Total number of polymer chains: 1
• Total formula weight: 21482.45

Authors

Kukimoto-Niino, M.,Shirouzu, M.,Yokoyama, S.,Fukui, Y.,Uruno, T. (deposition date: 2020-07-22, release date: 2021-02-10, Last modification date: 2023-11-29)

• Primary citation: Sakurai, T.,Kukimoto-Niino, M.,Kunimura, K.,Yamane, N.,Sakata, D.,Aihara, R.,Yasuda, T.,Yokoyama, S.,Shirouzu, M.,Fukui, Y.,Uruno, T.; A conserved PI(4,5)P2-binding domain is critical for immune regulatory function of DOCK8.; Life Sci Alliance, 4:-, 2021; PubMed: 33574036; DOI: 10.26508/lsa.202000873

Experimental method

X-RAY DIFFRACTION (1.432 Å)